Using RNAi Technology Against BSE and CJD


Scientists may be on to a novel approach for the development of therapeutics against neurodegenerative diseases such as bovine spongiform encephalopathy (BSE, also known as “mad cow disease”) and Creutzfeldt-Jakob Disease.

Using RNAi technology, they have been able to demonstrate in vitro that the genes coding for PrPsc, an abnormally folded protein that accumulates in the brain typical of BSE and CJD, may be silenced.

The study has been published in a recent issue of the Journal of Clinical Investigation.


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