11 New Cardiovascular Risk Gene Variants Identified


In addition to 19 other variants previously reported, 11 new gene variants have been identified that are associated with three blood lipids measured to determine cardiovascular disease risk (low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) and triglycerides). These findings were published in the Dec. 7, 2008 online publication of Nature Genetics.

The study is a meta-analysis of over 20,000 subjects in genome-wide association studies of humans in the United States and Europe with The Framingham Heart Study accounting for the largest number of samples. “Having identified a total of 30 gene variants is a landmark in lipid research,” says Ordovas, also a professor at the Friedman School of Nutrition and Science Policy at Tufts and Tufts University School of Medicine “It suggests people can have multiple variant genes contributing to dyslipidemia, a combination of spiked LDL and triglyceride levels and extremely low HDL-cholesterol signaling cardiovascular disease risk.


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