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Yoghurt Bugs Engineered To Produce HIV-Drug

Filed in archive Drugs, Vaccines and Therapeutics , Microbiology by ruth on February 1, 2006

Lactic acid bacteria (LAB) is a group of microorganisms commonly used for manufacturing milk products such as cheese and yoghurt. A research team from the Brown Medical School successfully engineered LAB to produce cynovirin in vitro, a protein that binds to HIV and prevents it from entering human cells in the mucous membranes.

"We've found that you can engineer these bugs to secrete drugs - in this case, a viricide that disables HIV," said Bharat Ramratnam, assistant professor of medicine at Brown Medical School and attending physician at Rhode Island Hospital and The Miriam Hospital. "The hope is to use the bacteria as the basis for a microbicide which can prevent sexual transmission of HIV."

Animal trials will begin mid-year to test its efficacy, and Ramratnam is hopeful to have a treatment ready for human clinical trials in three years.

Source: Brown Medical School

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Add your response to Yoghurt Bugs Engineered To Produce HIV-Drug: Response from: alfa (04/02/06 11:48pm) Let's just hope and pray that they get to fully develop the drug from these LAB before the HIV mutates further. Response from: Drug Treatment (05/17/07 5:28am) Has this bacteria been used in real life or are these only speculations ? I wonder if this could work. I always believed that all the solutions are around us, life can be used to alter or fix everything Response from: Aetiology Welcome to the introductory edition of Animalcules!! Our first, and most pressing, issue is the name. As was pointed out in the comments here, there's already a monthly column in Microbe (formerly ASM News) called "Animalcules." But I still like...
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Yoghurt Bugs Engineered To Produce HIV-Drug

Filed in archive Drugs, Vaccines and Therapeutics , Microbiology by ruth on February 1, 2006

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