biotech
Yeast Model As Tool For Alzheimer's Disease Drug Discovery
Filed in archive Diagnostics, Methodologies and Instrumentation , Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics by ruth on November 29, 2006
Yeast Model As Tool For Alzheimer's Disease Drug Discovery
Scientists re exploring the use of a yeast model as a tool in screening drug candidates that may be treat Alzheimer's Disease (AD) during its early stages. The model is based on the findings that AD is characterized by formation of beta-amyloid plaques in the brain.
"We've developed a yeast model system in which A-beta small aggregate formation can be detected," said Liebman. "The system employs a fusion of the human A-beta peptide to a functional yeast protein, called a reporter protein, which is only active in allowing cells to grow on test media if the fusion does not form aggregates."

[The author] said the yeast model system can be used to develop a high throughput assay to screen small molecules to find those that inhibit the A-beta dependent aggregation. "We'll screen a library of drugs and compounds, looking for ones that allow our yeast with the reporter protein to grow."

Preventing the formation and accumulation of these aggregates may thus prevent the progression of AD. The study has been published online in BMC Biology.

[Souce: University of Illinois, Photo: AβMRF causes nonsense suppression in yeast, click here for larger image and full caption]

Permalink: Yeast Model As Tool For Alzheimer's Disease Drug Discovery
Tags: drug+discovery  proteomics  genomics  Alzheimer  alzheimers+disease  biotech  yeast+model  alzheimer+diseas 
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/44146
img Addthis img Ask img Blinklist img del.icio.us img Digg img Fark img Facebook img Google img Lycos img Ma.gnolia Add this page to Mister Wong Mr Wong img Netscape img Netvousz img Newsvine img Reddit img StumbleUpon img Slashdot img Tailrank img Technorati img Wink img Yahoo

Vote for Yeast Model As Tool For Alzheimer's Disease Drug Discovery:

  • Currently 7.60/10
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
Rating: 7.60 out of 5 vote(s) cast.
 
Subscribe
Share It
Popular posts from our other blogs:
RSSrss
See all blog subscribe options
Google google
What is RSS?
Yahoo! yahoo
Addthis Subscribe using any feed reader!
Bloglines Bloglines
Newsletter

TwitterFollow us on Twitter!