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Drugs, Vaccines and Therapeutics
by ruth on September 27, 2006
...mice with [experimental autoimmune encephalitis] who received daily nicotinamide injections under their skin had a delayed onset of neurologic disability, and the severity of their deficits was reduced for at least eight weeks after treatment. The greater the dose of nicotinamide, the greater the protective effect
Nicotinamide appears to increase the nicotinamide adenine dinucleotide (NAD) levels in the spinal cord, which protects the axons from degeneration. Nicotinamide is an inexpensive and readily available vitamin, but as the doses that would be required for humans will be much higher than that used in these animal trials, a clinical study will have to be set up to test its safety and efficacy.
[Photo: In mice with MS-like disease, nicotinamide delayed and reduced neurologic disability as indicated by behavioral scores. Source: CHB]
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/36991
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