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Drugs, Vaccines and Therapeutics
by ruth on November 30, 2007
The UCSD investigators have shown that cobinamide binds relatively tightly to nitric oxide (NO), forming nitrosyl-cobinamide. Because the binding is reversible, nitrosyl-cobinamide can be used as a NO donor. NO is produced by most cells in the body, and helps regulate a variety of physiological functions including maintaining blood pressure, optimizing heart function, and serving as a neurotransmitter.
Preliminary data on animals and isolate mouse hearts have shown that the drug acts similarly as current drugs for angina, nitroglycerin and sodium nitroprusside. As a vitamin B12 analog, it appears to be non-toxic at the doses that would be required to treat angina or acute hypertension. Further pre-clinical and pharmacokinetic studies are ongoing.
The results of this study will apear in the December issue of Experimental Biology and Medicine.
Source: EurekAlert
Tags:
angina
heart+disease
cardiovascular+disease
nitroglycerin
biotech
nitrosyl+cobinamide
biotech+center
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/104701
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