biotech
Vitamin B12 Derivative Nitrosyl-Cobinamide May Treat Heart Disease
Filed in archive Drugs, Vaccines and Therapeutics by ruth on November 30, 2007
Vitamin B12 Derivative Nitrosyl-Cobinamide May Treat Heart Disease
Researchers have developed a new drug called nitrosyl-cobinamide which may be used to treat hypertension and other heart diseases. Cobinamide is a vitamin B12 analog, and, in fact, is the penultimate compound in the biosynthesis of vitamin B12 by bacteria.
The UCSD investigators have shown that cobinamide binds relatively tightly to nitric oxide (NO), forming nitrosyl-cobinamide. Because the binding is reversible, nitrosyl-cobinamide can be used as a NO donor. NO is produced by most cells in the body, and helps regulate a variety of physiological functions including maintaining blood pressure, optimizing heart function, and serving as a neurotransmitter.

Preliminary data on animals and isolate mouse hearts have shown that the drug acts similarly as current drugs for angina, nitroglycerin and sodium nitroprusside. As a vitamin B12 analog, it appears to be non-toxic at the doses that would be required to treat angina or acute hypertension. Further pre-clinical and pharmacokinetic studies are ongoing.

The results of this study will apear in the December issue of Experimental Biology and Medicine.

Source: EurekAlert

Permalink: Vitamin B12 Derivative Nitrosyl-Cobinamide May Treat Heart Disease
Tags: angina  heart+disease  cardiovascular+disease  nitroglycerin  biotech  nitrosyl+cobinamide  biotech+center 
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/104701
img Addthis img Ask img Blinklist img del.icio.us img Digg img Fark img Facebook img Google img Lycos img Ma.gnolia Add this page to Mister Wong Mr Wong img Netscape img Netvousz img Newsvine img Reddit img StumbleUpon img Slashdot img Tailrank img Technorati img Wink img Yahoo

Vote for Vitamin B12 Derivative Nitrosyl-Cobinamide May Treat Heart Disease:

  • Currently 9.50/10
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
Rating: 9.50 out of 4 vote(s) cast.
Subscribe
Share It
RSSrss
See all blog subscribe options
Google google
What is RSS?
Yahoo! yahoo
Addthis Subscribe using any feed reader!
Bloglines Bloglines
Newsletter

TwitterFollow us on Twitter!