Triterpenoids Isolated from Apple Peels with Anticancer Activity
Filed in archive Drugs, Vaccines and Therapeutics , Food and Agriculture by ruth on May 22, 2007

With higher antiproliferative activity toward HepG2 cancer cells:
- 2-hydroxyursolic acid
- 2-hydroxy-3-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid
- 3-trans
-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid
Higher antiproliferative activity against MCF-7 cancer cells:
- 2-hydroxyursolic acid
- 2-hydroxy-3-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid
- 3-trans-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid
All triterpenoids tested showed antiproliferative activity against Caco-2 cancer cells, especially:
- 2-hydroxyursolic acid
- 2-hydroxy-3-{[(2E)-3-phenyl-1-oxo-2-propenyl]oxy}olean-12-en-28-oic acid
- 3-trans-p-coumaroyloxy-2-hydroxyolean-12-en-28-oic acid
The study has been published in the J. Agric. Food Chem.
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cancer
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