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Drugs, Vaccines and Therapeutics
by ruth on September 5, 2006
"These results represent the first time gene therapy has been used successfully to treat cancer. Moreover, we hope it will be applicable not only to melanoma, but also for a broad range of common cancers, such as breast and lung cancer," said NIH Director Elias A. Zerhouni, M.D.
The process involved what is called an adoptive cell transfer:
Lymphocytes are harvested from the patients with advanced melanoma. The cells are then infected with a retrovirus which carries and delivers genes that encode specific proteins called T cell receptors (TCRs). When TCRs are expressed on the outer surface of the lymphocytes, the cells recognize and bind to certain molecules found on the surface of tumor cells, which are then destroyed by the lymphocytes.
Read more from the National Cancer Institute or read the scientific paper published in Science Express.
[Photo: NCI]
Permalink: Treating Advanced Melanoma With Gene Therapy
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