biotech
Studying Tyrosine Kinase Src and Cancer Drug Discovery
Filed in archive Diagnostics, Methodologies and Instrumentation , Drugs, Vaccines and Therapeutics by ruth on March 10, 2006
Studying Tyrosine Kinase Src and Cancer Drug Discovery
Researchers from John Hopkins identified a novel method to study tyrosine kinase Src, an important protein implicated in cancer. An inactivated, mutated version of the Src protein, which could again be rendered functional by a small molecule called imidazole, was inserted into live animals. According to the research, published in Science last week, not only helped understand the mechanism of Src's action, but also identify potential treatment leads.

"Understanding the functions of different proteins in normal states and disease states is crucial for treatment development because it can help identify new therapeutic targets," says Cole. Insights into tyrosine kinases could be particularly important for determining new cancer treatments, since scientists think that many different types are involved. "For example, Gleevec, which is used to treat gastrointestinal stromal tumors and chronic myeloid leukemia, is the most successful magic bullet against cancer in many years and works by blocking tyrosine kinase activity," Cole says.


According to Cole and the other authors, they plan to adapt their approach to develop a method to screen drug candidates, and possibly to apply the same principle to other genetic diseases.

Read more from John Hopkins.

Permalink: Studying Tyrosine Kinase Src and Cancer Drug Discovery
Tags: cancer  proteomics  biotech  drug  tyrosine  tyrosine+kinase  cancer+drug  drug+discovery 
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