Studying Macrolide Formation Paves Way for Novel Antibiotics
Filed in archive Drugs, Vaccines and Therapeutics by ruth on September 20, 2006

. By studying how enzymes produce antibiotics from precursor molecules, novel antibiotics may be produced. Scientists from the University of Michigan's Life Sciences Institute and University of Minnesota College of Pharmacy have, for the first time, been able to crystallize an enzyme in the process of closing the antibiotic ring, which illustrates exactly how the ring is formed."These findings are likely to enable the development of powerful new methods to build structural diversity into large ring systems that are a key component of many types of macrolide antibiotic molecules. This will provide yet another strategy to stay ahead of the emerging and persistent antibiotic resistance threat," Sherman said.
The researchers believe that bacterial cells may be manipulated such that new antibiotic-candidates may be produced within the cell. The study has been published in Nature Chemical Biology.
Read more from the Univ. of Minnesota News Release.
[Photo: www.siue.edu]
Permalink: Studying Macrolide Formation Paves Way for Novel Antibiotics
Tags:
antibiotics
MRSA
antibiotic+resistance
antimicrobial
macrolide
biotech
novel+antibiotics
studying+ma
Trackback: http://www.creative-weblogging.com/cgi-bin/mt-tb.pl/36715

Mr Wong
