Social Aversion Symptoms In Clinical Depression Traced

Filed in archive Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics on February 17, 2006

Researchers from the Florida State University used a gene transfer technique (in mice) to block the expression of a gene which associated with clinical depression. The results could lead to better treatment of human beings with this condition.

The research team identified the role of a gene called Brain Derived Neurotrophic Factor (BDNF) in the development of social aversion. Their results were published in the Feb. 10 issue of Science.

The researchers found that long-term use of antidepressants, such as fluoxetine (Prozac) and imipramine (Trofanil), were successful in reversing the social withdrawal in these mice. But the successful use of the gene therapy approach to block the expression of the BDNF gene in a highly localized area of the brain suggests the potential for the development of new drug therapies with fewer side effects.

Researchers state that the findings of this study may provide new leads and point to potential strategies in drug development for clinical dpression, such as developing drugs capable of targeting specific proteins in restricted brain areas.

Source: FSU NewsHat Tip: Gloria Gamat