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Drugs, Vaccines and Therapeutics
by ruth on April 16, 2007
The molecular focus of this report was on nuclear factor ΚB (NF- ΚB), an anti-apoptotic transcriptional factor that is constitutively activated in AICAP cell lines. The scientists showed that SVT inhibited growth of AICAP cells lines PC-3 and DU145 with IC50's of 1.7 and 1.8ug/mL, respectively. This exceeded the IC50 in LNCaP, androgen-sensitive cells (9.1ug/mL). With increasing concentrations of SVT, the number of cells distributed in the S phase of the cell cycle decreased significantly compare with cells in other phases.
According to the results of the study, a nanogram concentration range of SVT appears to inhibit the growth of AICAP through the NF-{kappa}B signal-mediated induction of cell death.
Photo: Macrovipera lebetina turanica, Wikipedia
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