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Drugs, Vaccines and Therapeutics
by ruth on December 28, 2007
The antibody, rituximab (anti-CD20), depletes B cells. Experimental evidence in mutant mice indicates that B cells play a role in autoimmune diseases by interacting with T cells of the immune system. It is T cells that destroy insulin-producing cells directly in the pancreas, leading to type 1 diabetes.
"Our paper shows, for the first time, that after successful B cell depletion, regulatory cells emerge that can continue to suppress the inflammatory and autoimmune response even after the B cells return," said Li Wen, senior research scientist in the division of endocrinology. "Even more strikingly, we found that these regulatory cells include both B and T cells."
The study has been published this month in the Journal of Clinical Investigation.
Source: Yale
Permalink: Rituximab Antibody may Treat Type 1 Diabetes
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/108606
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