Protein Biomarkers in Urine for Bovine Spongiform Encephalopathy (BSE)
Filed in archive Genomics, Proteomics and Bioinformatics by ruth on September 11, 2008
Researchers have identified proteins in urine samples which may be used as an indicator of the presence and progress of Bovine Spongiform Encephalopathy (BSE) disease in cattle.
The researchers say these findings, published in the journal Proteome Science, may be used to develop a biomarker test for the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies.
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The scientists analysed the proteins in urine samples taken from four infected and four healthy cows of the same age over the course of the disease. The proteins from the healthy and infected samples were compared using a technique called two-dimensional differential-gel electrophoresis (2-D DIGETM)
In these preliminary results a single protein was able to distinguish between those infected and control animals. In addition, the relative abundance of a set of proteins could accurately determine how far the disease had advanced.
The researchers say these findings, published in the journal Proteome Science, may be used to develop a biomarker test for the diagnosis and monitoring of disease progression in BSE and related transmissible spongiform encephalopathies.
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BSE CJD mad+cow proteomics biomarkers diagnostic+test 2007 spongiform+encephalopathy
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