Protein Biomarkers for Colorectal Cancer Identified
Filed in archive Diagnostics, Methodologies and Instrumentation , Gene Therapy , Genomics, Proteomics and Bioinformatics by ruth on September 24, 2007

"This study found two novel proteins which have never been found to be associated with colorectal cancer. We clearly demonstrated that absence of mimecan and up-regulation of TXNDC5 were involved in the early development of colorectal cancer," said the article's first author Yinghong Wang. "Our further work showed that mimecan can inhibit cell growth and induce cell apoptosis in colorectal cancer cells implying a candidate role as a tumor suppressor gene for the mimecan gene. These results suggested that mimecan might serve as a potential biomarker for future gene therapy."The identification of these biomarkers could improve the early detection and prevention of colorectal cancer. The study will be published in the October issue of Experimental Biology and Medicine.
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cancer genomics proteomics gene+therapy biomarkers diagnostics colon+cancer colorectal+cancer colore
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