Proline Dehydrogenase Model Reveals Role in Apoptosis
Filed in archive Diagnostics, Methodologies and Instrumentation , Genomics, Proteomics and Bioinformatics by ruth on May 13, 2007

and bioninformatics to create a model.
"The three-dimensional model tells us a lot about the structure of the molecules and helps us understand how they work," Tanner said. "This protein is important in cancer prevention because it enables the creation of superoxide, which aid in cell death. Cells aren't meant to live forever, and at some point, they need to die and be destroyed. Cells that are damaged or diseased are usually destroyed in this process. Our structure tells us how oxygen gets access to electrons stored in the enzyme. We think we've identified a gate that opens to let oxygen into the enzyme where the electrons are stored."The researchers next aims to identify molecules that inactivate proline dehydrogenase and thus gain more insight in the anti-cancer abilities of this molecule.
Source: University of Missouri-Columbia
Photo: Nanonet
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proteomics apoptosis model bacterial+model proline+dehydrogenase cancer bioinformatics biotech biote
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