biotech
Polymer Nanoparticle Uptake in an In Vitro 3-D Brain Tumor Co-Culture Model
Filed in archive Diagnostics, Methodologies and Instrumentation , Nanomedicine by ruth on August 27, 2007
Polymer Nanoparticle Uptake in an In Vitro 3-D Brain Tumor Co-Culture Model

Photo:Fluorescence picture showing uptake of nanoparticles labelled with red fluorescence taken up principally by tumor cells labelled with green microparticles. Few nanoparticles can be seen on the brain slice (blue) underneath. Credit: Society for Experimental Biology and Medicine

A nanoparticle drug delivery system designed by University of Nottingham scientists for brain tumor therapy has shown promising tumor cell selectivity in a novel cell culture model. The nanoparticles were prepared from a novel biodegradable polymer, poly(glycerol adipate), which has been modified to enhance efficacy and allow incorporation of drugs.
In the cell co-culture model now reported, these two techniques have been brought together for the first time. Brain tumor cell aggregates were labeled with fluorescent iron microparticles and grown on normal newborn rat-brain tissue slices. The double cell labeling technique allowed investigation of tumor cell invasion into brain tissue by either fluorescence or electron microscopy from the same samples. Using these techniques the tumor aggregates were found to invade the brain slices in a similar manner to tumors in the body. Having developed the model then the tumor selective uptake of nanoparticles was demonstrated in the co-culture.

The project, conducted jointly in the Schools of Pharmacy, Biomedical Sciences and Human Development, is featured in the September issue of the Experimental Biology and Medicine.

Source: EurekAlert

Permalink: Polymer Nanoparticle Uptake in an In Vitro 3-D Brain Tumor Co-Culture Model
Tags: nanotechnology  nanoparticle  nanomedicine  biotech  tumor  brain+tumor  culture+model  biotech+center 
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/88300
img Addthis img Ask img Blinklist img del.icio.us img Digg img Fark img Facebook img Google img Lycos img Ma.gnolia Add this page to Mister Wong Mr Wong img Netscape img Netvousz img Newsvine img Reddit img StumbleUpon img Slashdot img Tailrank img Technorati img Wink img Yahoo

Vote for Polymer Nanoparticle Uptake in an In Vitro 3-D Brain Tumor Co-Culture Model:

  • Currently 10.00/10
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
Rating: 10.00 out of 1 vote(s) cast.
Subscribe
Share It
Popular posts from our other blogs:
RSSrss
See all blog subscribe options
Google google
What is RSS?
Yahoo! yahoo
Addthis Subscribe using any feed reader!
Bloglines Bloglines
Newsletter

TwitterFollow us on Twitter!