biotech
PlyPH: Novel Protein Against Anthrax
Filed in archive Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics by ruth on April 24, 2006
PlyPH: Novel Protein Against Anthrax
Scientists from the Rockefeller University report of having descovered a new protein that may be used for treatment and large-scale decontaminant against anthrax. A lysin protein called PlyPH was isolated from a bacteriophage and has been shown to have the following important properties:

  • functions over an extrmely wide pH range (pH 4-8), allowing it to work under various environmental conditions

  • bacteria-specific, therefore eliminates the problem of cross-resistance development


Fischetti hopes to combine PlyPH with a non-toxic aqueous substance developed by a group in California that will germinate any anthrax spores it comes in contact with. As the spores germinate, the PlyPH protein will kill them, usually in a matter of minutes. The combined solution could be used in buildings, on transportation equipment, on clothing, even on skin, providing a safe, easy way to fight the spread of anthrax in the event of a mass release.


The study is described in an article published in the Journal of Bacteriology: PlyPH, a Bacteriolytic Enzyme with a Broad pH Range of Activity and Lytic Action against Bacillus anthracis.

[Photo: A bacillus bacterium, a close relative of anthrax, begins to explode after being treated with PlyPH, from Rockefeller]

Permalink: PlyPH: Novel Protein Against Anthrax
Tags: anthrax  bioweapon  biotech  protein  plyph  against+anthrax  protein+against  plyph+novel 
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