Pine tree bark extracts which have also been shown to reduce Attention-Deficit/Hyperactivity Disorder (ADHD) symptoms have also been shown to be effective in treating leg ulcers in patients who suffer from diabetic leg ulcerations. Leg ulcers stem from impaired blood circulation in diabetics, and are diifcult to heal. If left untreated, they may lead to leg amputations. According to the results published in the Clinical and Applied Thrombosis/Hemostasis:

• Group 1 patients supplemented with oral and local Pycnogenol® experienced a 74.4 percent decrease in leg ulcer size.
• Group 2 patients supplemented with local Pycnogenol® experienced a 41.3 percent decrease in leg ulcer size.
• Group 3 patients supplemented with oral Pycnogenol® experienced a 33 percent decrease in leg ulcer size.
• Group 4, the control group, experienced a 22 percent decrease, from disinfecting the ulcers on a daily basis.
• Eighty-nine percent of the patients treated with oral and local Pycnogenol® were completely healed.

According to their press release, Pycnogenol® has also been shown to help with other complications associated with diabetes, such as high blood pressure, platelet aggregation, LDL cholesterol and impaired circulation.