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Genomics, Proteomics and Bioinformatics
by ruth on June 11, 2007
What they found is that healthy individuals more often have a protective DNA sequence in the interleukin-2 and interleukin-21 gene region than individuals with coeliac disease. Interleukin-2 and interleukin-21 are cytokine proteins secreted by white blood cells that control inflammation. It is likely that the protective DNA sequence leads to different amounts of these cytokines being produced -than in someone with coeliac disease- providing defence against intestinal inflammation.
Aside from providing insight into the disease, these findings may be a tool for identifying individuals who are more likely to develop coeliac disease, and may possibly lead to the development of new therapies. The study has been published online in Nature Genetics (10 June 2007).
Source: EurekAlert
Photo: Biopsy of small bowel showing coeliac disease manifested by blunting of villi, crypt hyperplasia, and lymphocyte infiltration of crypts. from Wikipedia
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/74883
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Vote for New Genetic Risk Factor for Coeliac Disease Identified:
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Response from:
Tunde Koltai
(04/07/08 10:34am)
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