Nestin: A Biomarker for Basal Epithelial Breast Cancer
Filed in archive Diagnostics, Methodologies and Instrumentation , Genomics, Proteomics and Bioinformatics on January 16, 2007
Last month, we reported on two proteins considered to be biomarkers for breast cancer metastasis onto neighboring lymph nodes. This time, a structural protein called nestinhas been linked to the incidence of basal epithelial breast tumors, a particularly deadly form of breast cancer. Since this type of breast cancer has a high rate of recurrence, testing for the nestin biomarker could lead to earlier detection and better treatment.
"Normal basal epithelial tissue produces nestin, but basal epithelial tumors produce a tremendous amount of nestin, which likely represents an abnormal expansion of the basal epithelia." DiRenzo said. "If it is indeed specific to regenerative cells, then it will make for an excellent diagnostic tool for a cancer of regenerative mammary cells."
Read more from the American Association for Cancer Research, or see the January 15 issue of the Cancer Research journal.
Tags: cancer diagnostics biomarker breast+cancer breast basal+epithelial nestin+biomarker
Vote for Nestin: A Biomarker for Basal Epithelial Breast Cancer:
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Rating: 8.67 out of 3 vote(s) cast.
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Response from:
Daniel Tzu-bi Shih
(11/25/07 3:29pm)
I agree the nestin is one of the essential biomarkers for epithelial derived cancers
Response from:
Dr.Mona
(12/23/07 3:35am)
if u pleasr inform me any recent papers abou nestin as a marker in breast cancer
Response from:
marcelo bianconi
(05/17/11 3:14pm)
I would like to know more information about NESTIN and any other biomarkers for BEBC and where can I perform the exact test to determine it. I live in Argentina,I´m a physician, not oncologist.My wife was dignosed with Ductal Invasive BC triple negative basallike (ER- PR- HER2- CK5/6+ EGFR focal).
Given the fact that in Argentina there´s no genomic testing and a low grade of oncologists she has received no treatment at all since she was performed surgery (Bilateral radical modified mastectomy)on Dic14th,2010.
I´d preciate if you could inform me of what I´ve already asked plus a more accurate diagnosis and where do you suggest to get it as well as treatment. I thank in advanced. MB.
Given the fact that in Argentina there´s no genomic testing and a low grade of oncologists she has received no treatment at all since she was performed surgery (Bilateral radical modified mastectomy)on Dic14th,2010.
I´d preciate if you could inform me of what I´ve already asked plus a more accurate diagnosis and where do you suggest to get it as well as treatment. I thank in advanced. MB.
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