Nanotechnology and Gene Therapy Against Stage IV Lung Cancer
Filed in archive Drugs, Vaccines and Therapeutics , Gene Therapy , Nanomedicine by ruth on April 24, 2007
The nanoparticle delivery system consists of a plasmid gene expression cassette loaded with DNA that encodes the FUS1 protein. This is wrapped tightly in a form of cholesterol to protect it from the body's defense mechanisms. The nanoparticles accumulate mainly in the lungs, particularly in the tumors, where the genes repeatedly express FUS1 tumor-suppressing proteins.
In the study, the median survival time for all patients is 14.6 months, which is considerably longer than the seven-month median survival time for patients receiving second line therapy. More details from the MD Anderson Cancer Center.
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