biotech
Nanotechnology and Gene Therapy Against Stage IV Lung Cancer
Filed in archive Drugs, Vaccines and Therapeutics , Gene Therapy , Nanomedicine by ruth on April 24, 2007
Gene Therapy for Cancer (Cancer Drug Discovery and Development)A preliminary clinical trial has demonstrated that an intravenuously administered nanoparticle containing the FUS1 gene shows clinical activity in stage 4 Lung Cancer Patients. FUS1 can induce apoptosis - programmed cell death - in cancer cells but is absent in those cells.
The nanoparticle delivery system consists of a plasmid gene expression cassette loaded with DNA that encodes the FUS1 protein. This is wrapped tightly in a form of cholesterol to protect it from the body's defense mechanisms. The nanoparticles accumulate mainly in the lungs, particularly in the tumors, where the genes repeatedly express FUS1 tumor-suppressing proteins.

In the study, the median survival time for all patients is 14.6 months, which is considerably longer than the seven-month median survival time for patients receiving second line therapy. More details from the MD Anderson Cancer Center.

Permalink: Nanotechnology and Gene Therapy Against Stage IV Lung Cancer
Tags: nanotechnology  nanomedicine  gene+therapy  cancer  lung+cancer  gene  therapy+against 
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