A new topical lotion developed by NanoBio Corporation, a spin-off company from the University of Michigan, has been shown to penetrate deep enough to treat onychomycosis, or toenail fungus, without beign systemically absorbed.

NB-002 is a topical oil-in-water nanoemulsion combined with an antimicrobial agent commonly used in oral products to treat gingivitis and other conditions of the mouth and throat. The nanoemulsion undergoes a high-energy process to shrink or "nano-size" the particles so they are small enough to enter the skin through pores and hair follicles but too large to penetrate the tight junctions of the epithelium.

Phase 2 clinical trials are ongoing and results are expected in early 2008.

Source: Nanobio