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Drugs, Vaccines and Therapeutics
, Genomics, Proteomics and Bioinformatics
, Microbiology
by ruth on January 25, 2006
In the Jan. 20 of Journal of Chemistry and Biology, researchers from the University of Wisconsin-Madison reports of a new method that may speed up the search for useful compounds in fungi. By turning off the production of a single fungal protein called LaeA, the research team claims to have found the switch that controls the production of secondary metabolites in Aspergillus nidulans a significant number of which yield potentially useful medical agents.
Thirty or so secondary metabolites await analysis in Aspergillus nidulans alone. Additionally, scientists suspect LaeA may play a similar role in all Aspergillus species, meaning there are over 180 fungi that can be mined using this technique. Keller also believes the mining strategy might work outside the Aspergillus genus with some modifications.Source: Univ Winsconsin-Madison
Photo Credit: A. nidulans mutants. Courtesy of Ron Morris, University of Medicine and Dentistry of NJ, via Broad Institute
Permalink: Mining Fungal Genomes For Lead Compounds
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Vote for Mining Fungal Genomes For Lead Compounds:
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Rating: 8.00 out of 2 vote(s) cast.
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Response from:
actualfactual
(01/27/06 8:25am)
Aspergillus is horrid. No really it is, it's a bitch to transform and my Honours project was to produce the linkage map at a certain Scottish uni - whilst cloning a gene responsible for copper uptake. Am I referenced anywhere? No. Has the data been published? Ha! Is working in an Aspergillus lab a good idea when you're an asthmatic triggered by atmospheric allergens? Hmmm.
Response from:
ruth
(01/31/06 8:09am)
actualfactual: haha! there's soemthing even more horrid: doing research that does NOT have anything to do with Aspergillus, but working in a lab full of Aspergillus researchers! Arrrrgh!!!!
ey, nice that you dropped by here!
ey, nice that you dropped by here!
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