Filed in archive
Drugs, Vaccines and Therapeutics
, Genomics, Proteomics and Bioinformatics
, Microbiology
by ruth on November 2, 2006

Professor Greg Challis and colleagues in the Chemistry Department of the University of Warwick have looked at the enzymes controlling the process that allows the bacterium Streptomyces coelicolor to create streptorubin B and have gained a clear understanding of which are the key enzymes that act at particular steps of that process. By manipulation of the enzyme content of the bacteria, they aim to produce a range of different compounds based closely on the form of streptorubin B normally formed by the bacteria. Some of these analogues of streptorubin B could provide the basis for developing useful new anti cancer drugs.
The study describing the biosynthetic pathway to the production of 4-methoxy-2,2-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics in Streptomyces coelicolor is published in Cehmical Communications.
[Photo: A colony of S. coelicolor bacteria that could be used to make a prodiginine such as streptorubin (shown in yellow). Source: University of Warwick]
Tags:
antibiotics
microbiology
cancer
chemotherapy
biotech
drug+candidates
microbially+produced
cancer+dru
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/41291
Mr Wong
Vote for Microbially Produced Antibiotics as Cancer Drug Candidates:
|
Rating: 7.60 out of 5 vote(s) cast.
|
Response from:
Drug Rehab Facility
(09/25/07 10:25am)
Anti-cancer drugs? What can sound better than that? I know things are not settled yet and there are still many researches to go but I would sure like to know what kind of cancer are these drugs for? I have been waiting for such news for a long long time now...
Subscribe
Use the search to look for other interesting posts
| RSS | See all blog subscribe options |
|
What is RSS? | |
| Yahoo! |
|
| Addthis |
|
| Bloglines |
|
| Newsletter | |
| Follow us on Twitter! |







