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Drugs, Vaccines and Therapeutics
, Genomics, Proteomics and Bioinformatics
by ruth on October 27, 2006

The third gene apparently coded for a protein that is part of the immune cell receptor for interleukin-23 (IL-23), an important mediator of inflammation in the body. Although several polymorphisms of IL-23 were associated with a significantly increased risk of developing IBD, one appeared to confer a very strong protection against IBD.
"We are not sure yet what it means in terms of improving treatments for IBD patients. But, we speculate that blocking the activity of IL-23 or manipulating its pathway will be an effective way to manage IBD.
Preliminary clinical trials indeed demonstrated that using monoclonal antibody that blocks IL-23 and a related inflammatory mediator did improve the conditions. These findings suggest that the IL-23 pathway may lead to more individualized, gene-targeted therapies for IBD.
For more details, see the feature report from the UPMC News Bureau, or the manuscript published in Science Express.
[Image: Schematic of patterns of disease in CD. The three most common sites of intestinal involvement in Crohn's disease are ileal, ileocolic and colonic. Source: Wikipedia]
Permalink: Interleukin Gene Linked to Crohn's Disease
Tags:
crohns
chrons+disease
inflammatory+bowel+movement
gene+therapy
genetics
colitis
gene
crohn+disease
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Mr Wong
Vote for Interleukin Gene Linked to Crohn's Disease:
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Response from:
RDoc
(11/01/06 9:52am)
What is about Interleukin 10 and CD 14. Are they linked to Chron's?
Response from:
RDoc
(11/01/06 9:55am)
What is about Interleukin 10 and CD 14. Are they linked to Chron's?
Response from:
RDoctor Medical
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Welcome to the November 14, 2006 edition of All things medical.Â
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