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Stem Cells
by ruth on November 22, 2008
Singapore researchers have developed pure insulin-producing cells from mouse embryonic stem cells (ESCs). The resulting cells have the same sub-cellular structures as the insulin-producing cells naturally found in the pancreas, were highly effective in treating diabetes in the mouse model.
These findings, published in two papers in the July 31 and August 8 online version of the journal stem cell Research, provide proof of principle that the same strategy could be applied to human ESCs to obtain similar pure insulin-producing cells.
Experiments by Dr Lim and Dr Li's group showed that when transplanted into diabetic mice with high blood glucose levels, the pure insulin-producing cells would cause the blood glucose levels of the animals to decrease.
In addition, it was discovered that none of the diabetic mice involved in the transplants developed teratoma, a type of tumour often associated with ESCs, which could complicate their use in therapeutic treatment. Furthermore, the pure insulin-producing cells managed to retain their insulin-production and glucose-sensing capacity over time.
These findings, published in two papers in the July 31 and August 8 online version of the journal stem cell Research, provide proof of principle that the same strategy could be applied to human ESCs to obtain similar pure insulin-producing cells.
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