Human Umbilical Cord Blood Cells Improve Alzheimer's Disease Indices
Filed in archive Stem Cells by ruth on March 28, 2008

Following a series of low-dose infusions of human umbilical cord blood cells into mice with Alzheimer's-like disease, the amount of amyloid-ß and ß-amyloid plaques-hallmarks of Alzheimer's pathology in the brain-was markedly reduced. Amyloid-ß induces an inflammatory response in the brain associated with the interaction of CD40 and CD40L, two pro-inflammatory molecules.
Human umbilical cord blood cell therapy was associated with suppression of CD40-CD40L activity, suggesting that this therapeutic approach modulatesthe activity of the immune system, offering the potential to target the pathogenic inflammatory response that may contribute to a variety of degenerative conditions, including Alzheimer's disease.
The study is published in the journal Stem Cells and Development (free full text access).
Permalink: Human Umbilical Cord Blood Cells Improve Alzheimer's Disease Indices
Tags:
cord+blood
alzheimer
AD
stem+cells
stemcells
cells
umbilical+cord
Trackback: http://www.creative-weblogging.com/cgi-bin/mt-tb.pl/118320


Mr Wong
