Haemophilus influenzae Aerosol May Protect Against Respiratory Pathogens

Filed in archive Drugs, Vaccines and Therapeutics , Microbiology on December 5, 2007

An aerosol preparation of live <span style=" />Haemophilus influenzae delivered to the lungs of mice has been found set off a healthy immune response and provided powerful protection against all four major classes of pathogens including those responsible for anthrax and bubonic plague.

Their "aerosolized lung innate immune stimulant," as the scientists have named the spray treatment, could benefit immune-compromised patients with cancer, HIV or other diseases as well as emergency workers and the general public facing uncommon threats like an aerosolized bioterror attack or a spreading respiratory epidemic.

According to Brenton Scott who with his postdoctoral advisor, Burton Dickey, developed the spray, the treatment works best if administered four to 24 hours before exposure. Nearly all mice survived when treated before exposure to lethal doses of anthrax, influenza, and the dangerous mold, Aspergillus. But, the treatment also has some benefit when given after exposure. Effectiveness declines over time but seems to last up to five days after a single dose.

Currently, preclinical testing is being completed, and clinical trials are being designed.

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