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Genomics, Proteomics and Bioinformatics
by ruth on September 18, 2007

The gene in question produces a protein that is involved in the immune defence system. It regulates the migration of white blood corpuscles to the kidneys and their work with neutralizing infectious bacteria. The Lund team has previously shown that the gene protects against renal pelvis inflammation in animal experiments. Now, in studies of children and adults with recurrent renal pelvis infections, they have also shown that mutations of this very gene are much more common in kidney patients than in healthy control individuals.
"We also saw that even patients without genetic changes have low levels of this protein. Therefore, a combination of a genetic examinations and a protein measurement could be a good way to find those who are most clearly in the risk zone," says Catharina Svanborg.
The full text of the study may be obtained from PLOS ONE (doi:10.1371/journal.pone.0000825).
Image: Medline Plus (Urinary track infections)
Tags:
genomics
UTI
urinary+track+infection
genetics
biotech
urinary+track
genetic+basis
basis+susceptibili
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/92172
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