biotech
Gene Therapy for Obesity
Filed in archive Genomics, Proteomics and Bioinformatics by ruth on March 10, 2009
Scientists may have found a promising new treatment for obesity using gene therapy. They have discovered that a particular gene called BDNF, can result in improved insulin sensitivity, reduced fat mass and weight loss when active in the hypothalamus.
According to first author Lei Cao, assistant professor in the department of molecular virology, immunology and medical genetics, the study involved injecting the BDNF gene in normal mice, diabetic mice and mice fed with a high fat diet, to determine how the gene transfer would affect their weight. "The gene was active in the overweight mice, but as they lost weight the gene expression was essentially 'dialed down,' using a novel RNA interference approach, thus stopping the weight from continuing to decrease and allowing a stable target weight to be reached," she says.

The findings have been published online in the journal Nature Medicine, and human trials are being planned.



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Tags: obesity  genetics  gene+therapy  gene  noscript  noscript+section  want+these 
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