Gene Plays a Role in Hair Loss Identified

Filed in archive Genomics, Proteomics and Bioinformatics on February 27, 2008

Researchers have identified a gene responsible for a rare hereditary form of hair loss known as hypotrichosis simplex. From the abstract of the paper published in Nature:

Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11-13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein-coupled receptor. Furthermore, we identified oleoyl-L-alpha-lysophosphatidic acid (LPA), a bioactive lipid, as a ligand for P2Y5 in reporter gene and radioligand binding experiments. Homology and studies of signaling transduction pathways suggest that P2Y5 is a member of a subgroup of LPA receptors, which also includes LPA4 and LPA5. Our study is the first to implicate a G protein-coupled receptor as essential for and specific to the maintenance of human hair growth.

The researchers are hopeful that these findings may be useful in discovering new therapeutic approaches to the treatment of hair loss.