Gene for Kidney Failure Identified

Filed in archive Genomics, Proteomics and Bioinformatics on April 30, 2008

Scientists have identified a gene known as Jund, which controls the activity of a group of cells thought to be responsible for potentially severe inflammation of the kidney. This discovery could offer a route for tackling the auto-immune destruction of kidney tissue which can occur in lupus patients, subsequently causing renal failure.

Jund regulates the activity of macrophages, cells which help us fight infection by eating up cellular debris and pathogens, and stimulating immune cells. The new research showed that when these cells are overactive, they can destroy healthy kidney tissue.

Professor Aitman, who led the Medical Research Council team, said: "We are hoping that this discovery will allow us to find a new and effective way of treating this potentially fatal form of kidney failure. By reducing the activity of the Jund gene, we were able to reduce activity of inflammatory cells that can become overactive in certain diseases of the kidney. Such a therapy would be of obvious benefit to patients suffering from auto-immune diseases such as lupus. This would allow them to avoid dialysis and maintain their quality of life."

The study has been published in nature genetics.