FDA Approves New Hyaluronic Acid Formulation As Dermal Fillers For Facial Wrinkles

Filed in archive Drugs, Vaccines and Therapeutics , Microbiology on June 7, 2006

From the makers of Botox comes another line of dermal fillers for the treatment of facial wrinkles and folds. The Juvederm gel family of products is composed of highly concentrated cross-linked hyaluronic acid, which, as shown in clinical trials results to a more natural and longer-lasting effects (up to six months).

Juvederm(R) is natural, biodegradable and currently the only approved hyaluronic acid dermal filler that has demonstrated its safety and effectiveness in patients of all skin types and colors. It also is the only hyaluronic acid dermal filler developed using a proprietary, technologically advanced manufacturing process that results in a malleable smooth gel that flows easily into the skin, creating a smooth, natural look and feel.

Accordign to Allergan's press release, Juvederm's formulation is superior to other hyluronic acid-based dermal fillers currently in the market, which use a gel particle suspension formulation. See demonstration video here.

There are three Juvederm formulations, depending on the degree of wrinkles:

• Juvederm(R) 24HV, a highly cross-linked formulation for more versatility in contouring and volumizing of facial wrinkles and folds;


• Juvederm(R) 30HV, a more highly cross-linked robust formulation for volumizing and correction of deeper folds and wrinkles; and


• Juvederm(R) 30, a highly cross-linked formulation for subtle correction of facial wrinkles and folds.

Juvederm is already available in Canada and some European countries.