Fat-Derived Stem Cells May be Used for Breast Reconstruction in Breast Cancer Patients

Filed in archive Diagnostics, Methodologies and Instrumentation , Drugs, Vaccines and Therapeutics , Stem Cells on October 29, 2006

University of Pittsburgh researchers are exploring the potential of using fat-derived stem cells to regenerate new breast tissue. If successful, this approach may represent a better option to recostructive surgery among breast cancer patients.

Dr. Rubin and his colleagues are focusing their efforts on an approach that involves combining the fat-derived stem cells with microscopic beads composed of a type of extracellular matrix (ECM) that has regenerative properties. Preliminary results indicate that the stem cells can easily attach themselves to these beads and are able to differentiate into mature fat cells. When injected under the skin in a rat model, the cellular combination eventually formed what they describe as a "mound" of tissue.

However, although fat or adipose stem cells have been shown differentiate into into soft tissue, scientists poin the need to demonstrate the effectivity and safety of using fat-derived stem cells taken from a breast cancer patient.

This reasearch is part of a three-year grant from the National Cancer Institute. Read further details from the UPMC News Bureau.

[Photo: Invasive Lobular carcinoma, Credit: Breastcancer.org]