Following an 11-3 result of a votation among the FDA Advisory panel, GlaxoSmithKline's weight-loss pill, Alli (60 mg orlistat, half the Dosage of Roche's Xenical), might be the first fat-blocking pill available in the market without prescription.

When taken with meals, orlistat blocks the absorption of about one-quarter of any fat consumed. That fat _ about 150 to 200 calories' worth _ is passed out of the body in stools, which can be loose as a result. About half of patients in trials experienced gastrointestinal side effects, the company said.

Of course, orlistat is no magic pill. There are side effects and is effective only for the duration of pill intake. However, it can be a tool that will help people control their calorie intake and modify their diet. The advisory panel requested Glaxo to continue follow-up studies should the product make it to the over-the-counter market, and to rework its label to ensure its proper use and avoid its abuse.

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