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Genomics, Proteomics and Bioinformatics
by ruth on May 10, 2006

Drawing on various databases, ENDEAVOUR gathers all the data about genes that are known to be connected with a disease or a biological process and integrates these data into a mathematical model. With the aid of this model, scientists study the similarities between the 'known genes' and genes whose biological function is not yet known. ENDEAVOUR then indicates whether these genes might possibly underlie a certain disorder.
Using the computer program, the developers tried to identify a gene that plays a role in a genetic disorder called DiGeorge syndrome, a rare congenital condition characterized by heart defects and abnormal facies among other symptoms. The computer program identified one possible disease gene, YPEL1, the lack of which was also confirmed in zebra fish models to manifest the disease.
ENDEAVOR may be downloaded here or here.
[Source: VIB: Scientists develop ENDEAVOUR, a computer program for identifying disease genes (pdf file)]
Tags:
genomics
bioinformatics
biotech
genes
disease
computer+program
endeavour+computer
identifying+diseas
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