biotech
Eight Genes That Help Predict Patients Response to Melanoma Treatment
Filed in archive Genomics, Proteomics and Bioinformatics by ruth on May 31, 2009
Eight Genes That Help Predict Patients Response to Melanoma Treatment
A group of researchers have identified eight genes that help predict a melanoma patient's response to treatment.
Dr. Tawbi and his colleagues examined the tumor tissues of 21 patients with metastatic melanoma, some of whom responded to chemotherapy and some who did not. Once the cases were divided, the researchers used a mathematical tool called Neural Network Analysis to survey over 25,000 genes and the regulators that turn the genes on and off to see if they could identify ones that could distinguish responders from nonresponders.

"Cancer cells contain massive amounts of information that, if analyzed appropriately, may inform us how to kill them," said Dr. Tawbi. "They contain thousands of genes, and every gene has a switch that turns it on or off. Neural Network Analysis, which utilizes pattern recognition algorithms, helped us identify a signature of eight genes and their switches that predict a patient's likelihood of responding to treatment for metastatic melanoma."

These eight genes are being validated in a larger sample of 80 patients.


Permalink: Eight Genes That Help Predict Patients Response to Melanoma Treatment
Tags: melanoma  cancer  skin+cancer  genomics  genes  eight+genes  help+predict  melanoma+treatment 
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