Drug Candidates from Marine Animals

Filed in archive Drugs, Vaccines and Therapeutics on July 8, 2008

Photo courtesy of iStockphoto, Martin Strmko

Scientists have isolated compound from marine animals which interfere with a protein termed NF-kB and may thus have potentials for treating cancer, as well as a number of other diseases including inflammatory bowel disease, arthritis and asthma.

"We have tested a large number of marine species to see which can prevent NF-kB from working," explains Professor Jaspars. "A few animals, including sponges, soft corals and sea lilies, were examined further, and from these we have been able to isolate and characterise the compounds responsible. We have shown that one of these molecules is able to allow normal cell death (which NK-kB switches off in some cancerous cells) to start up again, a property which we will be going onto study in much more detail."

In addition, they have also isolated molecules from a species of sponge that may aid in drug delivery.

"It is an unfortunate reality that currently, many new excellent drugs are discovered that cannot be delivered effectively to the places where they are required," Professor Jaspars reveals. "However, we have isolated one compound from a Mediterranean sponge that may help to end this trend. This molecule can reversibly create pores in cell membranes, a property for we envisage vast possibilities in the transportation of medicinal drugs. As we can now make this compound in the lab in large quantities, we are now able to investigate possible applications of the molecule, including drug delivery into tumours, gene delivery for cystic fibrosis and delivery of drugs into the eye."

The findings were presented during the Society for Experimental Biology's Annual Meeting in Marseille, France.

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