Drug and Vaccine Delivery Using Self-exploding Microcapsules

Filed in archive Diagnostics, Methodologies and Instrumentation , Drugs, Vaccines and Therapeutics on January 4, 2006

Researchers from Ghent University and the Universite Catholique de Louvain have developed a novel method of drug delivery that allow sequential release following a single administration.

Unlike some other microcapsules, which release their drug cargo only when exposed to ultrasonic waves or another external trigger, the new system relies on internal mechanisms to do the same job. Each of the new microparticles features a biodegradable gel core that is surrounded by a lipid membrane. As the gel biodegrades, pressure builds up in the membrane. Eventually the microcapsule ruptures, releasing the medication.

The system could allow certain vaccines to be given in a single shot, with the "booster" microcapsules timed to rupture at appropriate intervals, eliminating the need for subsequent booster injections. The research will be published on the Jan. 9, 2006 print issue journal Biomacromolecules.

Source: ACS News Service