DNA Vaccine Against DLL4 Protein Slows Down Cancer
Filed in archive Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics on May 25, 2010
© WIkipediascientists at the Karolinska Institutet have a developed a DNA vaccine targeted at a protein known as 'Delta-like ligand 4' (DLL4), which has recently been identified as an important component in regulating the formation of new blood vessels. By blocking the expression of DLL4 in a tumour, new, but non-functional, blood vessels, are formed, slowing down tumor growth.
Results from an animal trial have shown that vaccination against DLL4 causes an immunological antibody response to DLL4, hindering the growth of breast cancer in mice.
Tumours from vaccinated mice had a tightly packed network of non-functional blood vessels, and poor blood supply. The vaccination did not cause any undesired effects and did not affect the animal's capacity for wound healing.
The study has been published online in the May 24 issue of the journal Oncogene.
Source
© WIkipedia
Tags: cancer vaccine genetics DNA+vaccine biotech against+dll4 vaccine+against down+cancer
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