Filed in archive
Drugs, Vaccines and Therapeutics
, Gene Therapy
, Genomics, Proteomics and Bioinformatics
by ruth on August 15, 2007

The researchers found that metformin instructs cells to switch metabolic pathways. Instead of using the most energy efficient pathway - called oxidative phosphorylation - the cells are forced to use stress-related ones, which are typically used when the cell is short on oxygen, glucose or other nutrient sources. But in the absence of p53, the cells can't make the switch. "Without p53, if we force cells to live on alternative substrates, they can't do it," explains Thompson.
As p53 is lacking in more than 50% of all human cancers, metformin seems to be a promising drug for use in cancer therapy, also considering that the drug is already approved as a therapeutic for human use. The results of the study has been published in Cancer Research.
Source: University of Pennsylvania School of Medicine
Permalink: Diabetes Drug Metformin Ma Slow Down Cancer
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/86411
Mr Wong
Vote for Diabetes Drug Metformin Ma Slow Down Cancer:
|
Rating: 9.43 out of 7 vote(s) cast.
|
Subscribe
Use the search to look for other interesting posts
| RSS | See all blog subscribe options |
|
What is RSS? | |
| Yahoo! |
|
| Addthis |
|
| Bloglines |
|
| Newsletter | |
| Follow us on Twitter! |







