Dengue Mosquito Genome Sequence

Filed in archive Genomics, Proteomics and Bioinformatics on May 21, 2007

The first draft of the genome sequence of Aedes aegypti, more commonly known as the yellow fever or dengue mosquito has been completed. The research is published online in Science.

We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at ~1.38 Gbp is ~5-fold larger in size than the genome of the malaria vector, Anopheles gambiae. Nearly 50% of the Aedes aegypti genome consists of transposable elements. These contribute to a ~4-6 fold increase in average gene length and the size of intergenic regions relative to Anopheles gambiae and Drosophila melanogaster. Nevertheless, chromosomal synteny is generally maintained between all three insects although conservation of orthologous gene order is higher (~2-fold) between the mosquito species than between either of them and fruit fly. An increase in genes encoding odorant binding, cytochrome P450 and cuticle domains relative to Anopheles gambiae suggests that members of these protein families underpin some of the biological differences between them.

Transposable elements discovered during research were classified and filed in TEfam, a central database established for submission, retrieval, and analysis of Aedes aegypti and Anopheles gambiae transposable elements.

These data could help in the development of insecticides or in the creation of genetically engineered mosquitos that are unable or less able to transmit the viruses which cause yellow fever or dengue fever.

More details from the press release at EurekAlert and Reuters report.

Photo: USDA