In the Journal of Inflammation, scientists report that Progrado®, an extract from a rainforest tree called Croton palanostigma, had remarkably potent antioxidant properties and prevented the destruction of human cartilage by enzymes called matrix metalloproteinases (MMPs). According to the researchers, these enzymes cut collagen, which forms the backbone of the cartilage, during states of inflammation and alter the fabric that holds tissues together.

"This is the first time a natural product has been shown to directly block these molecular scissors while showing potential to stimulate repair. This is a testament to the wound healing properties of this traditional medicine and the distinctive therapeutic opportunities that nature offers."

These findings suggest a broad set of applications in various joint, skin and gastrointestinal diseases, including osteoarthritis and irritable bowel syndrome.

Source: EurekAlert
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