Chat with our sales team
Whole Network Most Recent TOP10 Gene Therapy Microbiology Nanomedicine Stem Cells

 

Collagenase Plays a Role in Multiple Sclerosis

Filed in archive Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics by ruth on March 29, 2008

Multiple_sclerosis.jpg
In animal trials, researchers have demonstrated that a protein called collagenase-2 plays a role in the development of multiple sclerosis, an autoimmune disease that causes various physical and mental symptoms, and often progresses to physical and cognitive disability. This discovery represents a potential new way to combat this debilitating disease.
Collagenase-2 is a member of a protein family called matrix metalloproteinases (MMPs, collagenase-2 is MMP8), a large group of enzymes that break down collagen and other components of the body's connective tissue. MMPs have been implicated in contributing to MS by degrading the tissue that maintains the blood-brain barrier, thus allowing unwanted cells to invade and break down nerves. In fact, MMPs are found in elevated amounts in the blood and spinal fluid of diseased individuals.

Using a mouse model of MS, Carlos Lopez-Otin and colleagues performed two analyses on MMP8 to determine how relevant this protein is to the disease. First, they developed mutant mice deficient in the gene for MMP8 and found that these mice had a fewer invading cells in the brain, fewer damaged nerves, and a general improvement in their clinical profile.

The study has been published in the March 28 issue of the Journal of Biological Chemistry.

Source


Advertisement


Permalink: Collagenase Plays a Role in Multiple Sclerosis
Tags: multiple+sclerosis  collagenase  2007  biotech  sclerosis  collagenase+plays  plays+role 

Trackback: http://www.creative-weblogging.com/cgi-bin/mt-tb.pl/118723



Advertisement


Advertisement


CW ToolbarInstall
RSSrss   | See all blog subscribe options
Googlegoogle   |   What is RSS?
Yahoo!yahoo
AddthisAddThis Feed Button
BloglinesBloglines
Newsletter
Advertisement - Book yours here.

Use our search feature to look for other interesting posts

Just this blog Whole network
Apple iTunes
Advertisement -
Book yours here..


 
  • Would you like to have a new interactive marketing channel for your company? Learn more about Sponsored Blogs with Creative Weblogging. See how we helped companies like Weblin and cellity reach their goals.
  • Would you like to reach millions of blog readers every day? See you banner on hundreds of blogs with TierOneAds? Stay in control measuring conversion in real time. Register now.
  • Would you like to make more money blogging? Use TierOneAds a new platform that allows you as a blogger to set your prices per impression. Register now.
  • Do you have a blog with more than 50k page views from the US? Let us market your blog and earn great fix payments and bonuses.
  • Would you like to see your text link here? Let us know!
Advertisement
Book yours here.



  • Testimonials

  • 'Very nice blog layout with great content. Are you interested in Star Trek props that are quickly becoming reality? Then this is the blog for you. Human medical scanners, nano technology and more great technological advancements.' -VirtualLoop Blog of the Week

    'I subscribe to your blog and have been enjoying your posts and perspective.'
  • Other blogs in the same channel in the Creative Weblogging Network

Advertisement -
Book yours here..






Advertisement - Book yours here..
 
Tagcloud: Biotech Hubs and Facilities Biotech/Science Blogs Corporate and Industrial News Diagnostics, Methodologies and Instrumentation Drugs, Vaccines and Therapeutics Energy, Environment and Ecology Food and Agriculture Gene Therapy Genomics, Proteomics and Bioinformatics Meetings and Other Events Microbiology Nanomedicine Other Biotechnology News Patents and Intellectual Property Rights Sponsored Post Stem Cells