biotech
Cloning Fosfomycin for More Cost-Effective Production
Filed in archive Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics , Microbiology by ruth on November 30, 2006
Cloning Fosfomycin for More Cost-Effective Production
Fosfomycin is a member of a class of compounds called phosphonic acids, a natural antibiotic approved by the FDA to control pathogens against which penicillin and vancomycin are no longer effective. It has also, for example, been demonstrated to be effective against Listeriosis in vivo. However, conventional production of fosfomycin by bacteria only yields low amounts.

By using cloning techniques, researchers at the University of Illinois at Urbana-Champaign were able to clone the essential genes for fosfomycin synthesis from Streptomyces fradiae and then produce it in a non-native host, Streptomyces lividians, potentially in much larger quantities. They also hope to be able to produce fosfomycin in Escherichia coli so that they can "use various protein and metabolic engineering tools to manipulate the fosfomycin biosynthetic pathway."

Aside form the success in cloning, the scientists were also able to identify the genes involved in the fosfomycin biosynthesis pathway and the function of these genes. The study has been published in a recent issue of the journal, Chemistry and Biology. For an overview, read the feature report from the Univ of Illinois at Urbana-Champaign.


Permalink: Cloning Fosfomycin for More Cost-Effective Production
Tags: fosfomycin  antibiotic  microbiology  cloning  genetics  genomics  biotech  cloning+fosfomycin 
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/44157
img Addthis img Ask img Blinklist img del.icio.us img Digg img Fark img Facebook img Google img Lycos img Ma.gnolia Add this page to Mister Wong Mr Wong img Netscape img Netvousz img Newsvine img Reddit img StumbleUpon img Slashdot img Tailrank img Technorati img Wink img Yahoo

Vote for Cloning Fosfomycin for More Cost-Effective Production:

  • Currently 9.50/10
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • 10
Rating: 9.50 out of 4 vote(s) cast.
 
Subscribe
Share It
RSSrss
See all blog subscribe options
Google google
What is RSS?
Yahoo! yahoo
Addthis Subscribe using any feed reader!
Bloglines Bloglines
Newsletter

TwitterFollow us on Twitter!