Cloning Fosfomycin for More Cost-Effective Production
Filed in archive Drugs, Vaccines and Therapeutics , Genomics, Proteomics and Bioinformatics , Microbiology by ruth on November 30, 2006

By using cloning techniques, researchers at the University of Illinois at Urbana-Champaign were able to clone the essential genes for fosfomycin synthesis from Streptomyces fradiae and then produce it in a non-native host, Streptomyces lividians, potentially in much larger quantities. They also hope to be able to produce fosfomycin in Escherichia coli so that they can "use various protein and metabolic
engineering tools to manipulate the fosfomycin biosynthetic pathway."Aside form the success in cloning, the scientists were also able to identify the genes involved in the fosfomycin biosynthesis pathway and the function of these genes. The study has been published in a recent issue of the journal, Chemistry and Biology. For an overview, read the feature report from the Univ of Illinois at Urbana-Champaign.
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fosfomycin antibiotic microbiology cloning genetics genomics biotech cloning+fosfomycin
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