Chitosan-Based Vehicle for Antioxidants

Filed in archive Diagnostics, Methodologies and Instrumentation on August 26, 2008

Photo courtesy of iStockphoto, Stephanie Horrocks

Researchers have designed a nano-sized "trojan horse" particle to aid in the absorption of antioxidants in the gut by protectin antioxidants from enzyme and acid breakdown.

The solution is to design a tiny sponge-like chitosan biopolymeric nanoparticle as a protective vehicle for antioxidants. Chitosan is a natural substance found in crab shells.

"Antioxidants sit within this tiny trojan horse, protecting it from attack from digestive juices in the stomach," Dr Larson said.

"Once in the small intestine the nanoparticle gets sticky and bonds to the intestinal wall. It then leaks its contents directly into the intestinal cells, which allows them to be absorbed directly into the blood stream.

"We hope that by mastering this technique, drugs and supplements also vulnerable to the digestive process can be better absorbed by the human body."

Clinical trials are slated for early next year.